Sevda Öğüt

PhD Candidate at  EPFL

Hey there! I'm Sevda — a senior computer science PhD student at EPFL. I'm interested in representation learning and its applications in biomedicine, especially digital pathology and spatial omics. I'm lucky to be supervised by Pascal Frossard and Dorina Thanou. Currently, I'm visiting the Lotfollahi Lab at Wellcome Sanger.

Previously, I worked on moleculer communication systems with Haitham Hassanieh. Prior to joining EPFL, I earned my BSc in electrical engineering from Bilkent University, where I had the chance to learn about multi-armed bandits with Cem Tekin.

In my free-time, I like to join EPIC events, play the piano 🎹, and travel 🗺!

P.S.
If you're an EPFL student searching a semester or thesis project, please check this project page.

If you'd like a summer internship at EPFL, please refer to Summer@EPFL or the E3 Program.

If you're interested in a PhD position, please check the EDIC program or the glamorous EPIC Guide.

News

Jun 2026
I started a research visit at the Lotfollahi Lab in Cambridge. Happy to chat! 🇬🇧
Jun 2026
Our work "DICE" is out on arXiv.
Mar 2026
Check the preprint of "GrapHist" on arXiv!
Jun 2025
Our work on image and graph representations in digital pathology is accepted at the ICML workshop FM4LS. See you in Vancouver! 🇨🇦
Mar 2025
Our paper on understanding the importance of graph structure in hierarchical GNNs is accepted at the ICLR workshop ICBINB.
Jul 2024
I attended the OxML Health and Bio summer school.
Sept 2023
I presented "MoMA" for SIGCOMM in New York City! 🇺🇸

Research

Preprints

DICE
Uncertainty Estimation in Pathology Foundation Models via Deep Mutual Learning
Aurel Tchokponhoue*, Sevda Öğüt*, Ali Idri, Dorina Thanou, Pascal Frossard
arXiv 2025

This paper proposes DICE, a plug-and-play framework that ensembles frozen pathology foundation models and models their disagreement as a proxy for uncertainty estimation. It provides reliable confidence estimates that flag failure-prone cases under in- and out-of-distribution settings, while matching or outperforming state-of-the-art baselines in classification, calibration, and localization.

GrapHist
GrapHist: Graph Self-Supervised Learning for Histopathology
Sevda Öğüt, Cédric Vincent-Cuaz, Natalia Dubljevic, Carlos Hurtado, Vaishnavi Subramanian, Pascal Frossard, Dorina Thanou
arXiv 2025

Instead of treating tissues as a grid of image tokens, we move toward a cell-centric representation with graphs, where nodes are detected nuclei and edges encode their spatial proximity. Our model learns structurally-aware embeddings through masked graph autoencoding and heterophilic GNNs, which generalize to downstream tasks across biological scales, from cell phenotyping to whole-slide survival analysis. We publicly release the full pipeline: code, model weights, and five new graph-based digital pathology datasets -- first of their kind 🚀

MIL
Instance-Level Explainability in Multiple Instance Learning
Sevda Öğüt, Aurel Tchokponhoue, Cédric Vincent-Cuaz, Manuel Madeira, Vaishnavi Subramanian, Dorina Thanou, Pascal Frossard
arXiv 2025

This study presents a unified benchmarking framework that evaluates MIL algorithms at both bag and instance levels, quantifying performance, learnability, and interpretability. Experiments on synthetic and digital pathology datasets reveal that although bag-level performance is robust across aggregation strategies, instance-level metrics are significantly affected by sample size and feature noise.

Publications

FM4LS
From Vision to Graph Self-Supervised Learning in Digital Pathology
Sevda Öğüt, Carlos Hurtado, Cédric Vincent-Cuaz, Natalia Dubljevic, Vaishnavi Subramanian, Dorina Thanou, Pascal Frossard
ICML Workshop Multi-modal Foundation Models and Large Language Models for Life Sciences 2025

This paper demonstrates that graph-based self-supervision captures spatial structure in digital pathology patches and achieves similar performance to vision-based models using 12x fewer parameters. It also shows late multi-modal fusion of images and graphs improves upon single-modal baselines.

ICBINB
On the Role of Structure in Hierarchical Graph Neural Networks
Luca Sbicego, Sevda Öğüt, Manuel Madeira, Yiming Qin, Dorina Thanou, Pascal Frossard

This analysis shows that graph structure is learned in the initial convolutional layers, typically before any pooling schemes are applied, by perturbing the input graph structure at varying depths of the hierarchical graph neural network. In fact, many popular benchmarking datasets for graph-level tasks only exhibit limited structural information relevant to the prediction task, with structure-agnostic baselines often matching or outperforming more complex GNNs.

MoMA
Towards Practical and Scalable Molecular Networks
Jiaming Wang, Sevda Öğüt,Haitham Al Hassanieh, Bhuvana Krishnaswamy

This work introduces MoMA, a molecular multiple access protocol that enables communication between multiple transmitters and a receiver in molecular networks. It addresses key challenges in molecular communication, such as lack of synchronization and high inter-symbol interference, and scales up to four transmitters in the synthetic testbed evaluation.

C3-MAB
Contextual Combinatorial Multi-output GP Bandits with Group Constraints
Sepehr Elahi*, Baran Atalar*, Sevda Öğüt*, Cem Tekin

This paper proposes TCGP-UCB which is an algorithm for combinatorial contextual bandit problems with privacy-driven group constraints. It balances between maximizing cumulative super arm reward and satisfying group reward constraints and can be tuned to prefer one over the other, with information-theoretic regret bounds.

UYMS
A Performance Study Depending on Execution Times of Various Frameworks in Machine Learning Inference
Murat Sever, Sevda Öğüt

This study benchmarks inference latency across multiple machine learning frameworks using a 2-layer neural network model. The model is implemented in PyTorch and converted to TorchScript and ONNX formats. Inference is performed using LibTorch, ONNX Runtime, and TensorRT on both CPU and GPU. Results show that TensorRT with ONNX delivers the fastest performance, demonstrating its efficiency and potential for deployment scenarios.

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Fun Stuff 🎉

Bikes I Have Named

Check this document to see the names I have given to my friends' bikes!

Let me know if you want your bike to be named and added to this list.